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Before you begin writing your proposal, make certain that you understand the mission of the funding agency to which you are applying. The mission of the NIH is to improve the health of the people in the U.S. No matter how scientifically important your work may be, no funding agency will support your proposal if it does not support the agency’s mission. For example: You would never dream of applying to the American Heart Association for a proposal to investigate cancer. 1. The Specific Aims The specific aims state what you want to do in the order in which you want to do it. But it is one which can be avoided by writing a highly focused grant application developed to test a hypothesis. 2. The Background and Significance The background and significance section serves several purposes, which are often misunderstood. It is not a literature review, as is commonly believed. Research Design and Methods
The research design and methods section comprises by far the longest section of the research plan; approximately half of the pages in the research plan are devoted to it.

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